Maria O. Longas

Professor of Chemistry

Education

Ph.D. Chemistry, New York University, 1978

 

Contact Information

Department of Chemistry and Physics
Purdue University Calumet
2200 169th Street
Hammond, IN 46323-2094

 

Office:	Gyte 269
Phone:	219-989-2286
Fax:	219-989-2130
Email:	mol@calumet.purdue.edu

 

Student Project Website

 

Research Interests

Structural basis for the 2d- and 3d- structures of hyaluronan in solution.

 

Enzymes involved in the age-mediated N-deacetylation of hyaluronan in whole skin and fibroblast cultures.

 

Infrared and Raman spectroscopy studies of heparin, in collaboration with Dr. Hari Garg of Harvard Medical School.

 

Localization of sulfate esters along the dermatan chain, using proton and 13C-nuclear magnetic resonance spectroscopy of the oligosaccharides generated upon digestion of dermatan sulfate with endoglycosidase enzymes of different specificities.

 

Nuclear magnetic resonance spectroscopy and Fourier transform infrared spectroscopy of sulfated oligoxylans, in collaboration with Dr. Audrey Stone of the National Institutes of Health.

 

Sulfatase and sulfotransferase enzymes of proteoglycan metabolism in adult human skin of varying ages (a tissue culture study).

 

The mechanism of action of Hyaluronan Synthase, in collaboration with Dr. A. Serianni of University of Notre Dame.

 

Teaching Interests/Specialties

Organic Chemistry

Biochemistry

Nuclear Magnetic Resonance Spectroscopy

Analytical Biochemistry

Glycoconjugates

 

Curriculum Vitae

 

Selected Publications

 

Longas, M. O., Oehlman, Susan, Trinkle Pereira, Jennifer A.: Evidence of Exo-Sulfatase Activity in Quail Egg White, Glycobiology, in press (2006).

Longas, M. O., Banerjee, D. and Xie, W.: Tunicamycin-Induced Apoptosis is Characterized by Protein Denaturation: An Infrared Spectroscopy Study, Glycobiology, 15, 11: 211 (2005)

Martinez, J. A., Tavarez, J. J., Oliveira, C. M., Sanchez, A., Baksi, K, Longas, M. O., Banerjee, D. K.: Differential Expression of Cytoplasmic Chaperones (HSP-70 & HSP-90) and ER Chaperons (GRPL-74/Bip & GRP-94) is a key to Tunicamycin-indiced  Unfolded Protein Response-Mediated  Apoptosis in Capillary Endothelial Cells, Glycoconjugate J., 22, 4-5-6:227 (2005)

Longas, M. O. Cheairs, K., Puchalski, M. L., Park, J.I.: Fourier Transform Infrared Spectroscopy in the Characterization of Skin, Glycobiology, 14, 11: 1174 (2004).

 

Longas MO, Hyaluronan in Aging. In: Chemistry and Biology of Hyaluronan. Garg, HG & Hales CA, Eds. Amsterdam: Elsevier Science (2004)http://sciencedirect.com/science/

 

Longas MO, *Burden JD, *Lesniak J, *Booth R, *McPencow JA, Park JI. Hyaluronic Acid N-Deacetylase Assay in Whole Skin. Biomacromolecules 2003; 4:189-192.

 

Longas MO, Garg HG, *Trinkle-Pereira JM, Hales CA. Heparin Antiprolipherative Activity on Bovine Pulmonary Artery Smooth Muscle Cells Requires Both N-Acetylation and N-Sulfation. Carbohydr. Res. 2003; 338:251-256.

 

* PUC students

 

Books

Reminiscencias - Classical Spanish Poetry,
by Maria Catrillon-Longas Matices Publications, ISBN 958-33-0587-1
© 1997.